- CITATIONS: 1
|Application ||WB, IHC-P, E|
|Other Accession||NP_001018059.1, NP_002562.2|
|Calculated MW||20624 Da|
|Antigen Region||73-101 aa|
|Other Names||Glycodelin, GD, Placental protein 14, PP14, Pregnancy-associated endometrial alpha-2 globulin, PAEG, PEG, Progestagen-associated endometrial protein, Progesterone-associated endometrial protein, PAEP|
|Target/Specificity||This PAEP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 73-101 amino acids from the Central region of human PAEP.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PAEP Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This protein is, quantitatively, the main protein synthesized and secreted in the endometrium from mid-luteal phase of the menstrual cycle and during the first semester of pregnancy.|
Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the kernel lipocalin superfamily whose members share relatively low sequence similarity but have highly conserved exon/intron structure and three-dimensional protein folding. Most lipocalins are clustered on the long arm of chromosome 9. The encoded glycoprotein has been previously referred to as pregnancy-associated endometrial alpha-2-globulin, placental protein 14, and glycodelin, but has been officially named progestagen-associated endometrial protein. Three distinct forms, with identical protein backbones but different glycosylation profiles, are found in amniotic fluid, follicular fluid and seminal plasma of the reproductive system. These glycoproteins have distinct and essential roles in regulating a uterine environment suitable for pregnancy and in the timing and occurrence of the appropriate sequence of events in the fertilization process. A number of alternatively spliced transcript variants have been observed at this locus, but the full-length nature of only two, each encoding the same protein, has been determined. [provided by RefSeq].
Soni, C., et al. Mol. Immunol. 47(15):2458-2466(2010)
Lee, C.L., et al. Fertil. Steril. 94(2):769-771(2010)
Tsviliana, A., et al. Anticancer Res. 30(5):1637-1640(2010)
Scholz, C., et al. Anticancer Res. 30(5):1599-1603(2010)
Amir, M., et al. Reprod. Biol. Endocrinol. 7, 152 (2009) :
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