|Application ||WB, E|
|Other Accession||P49651, P34996, P48042, NP_002554.1|
|Predicted||Bovine, Chicken, Rat|
|Calculated MW||42072 Da|
|Antigen Region||231-260 aa|
|Other Names||P2Y purinoceptor 1, P2Y1, ATP receptor, Purinergic receptor, P2RY1|
|Target/Specificity||This P2RY1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 231-260 amino acids from the Central region of human P2RY1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||P2RY1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation. [provided by RefSeq].
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Maloney, S.F., et al. Integr Biol (Camb) 2(4):183-192(2010)
Nisar, S., et al. Traffic 11(4):508-519(2010)
Kumar, T.S., et al. J. Med. Chem. 53(6):2562-2576(2010)
Bambace, N.M., et al. Platelets 21(2):85-93(2010)
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