|Application ||WB, IHC-P, E|
|Other Accession||P10669, Q90844, P50291, NP_006341.1, NP_037541.1, O62650, P31514|
|Predicted||Bovine, Chicken, Horse, Pig, Sheep|
|Calculated MW||38007 Da|
|Antigen Region||312-340 aa|
|Other Names||Follistatin, FS, Activin-binding protein, FST|
|Target/Specificity||This FST antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 312-340 amino acids from the C-terminal region of human FST.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FST Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).|
|Tissue Location||Isoform 1 is the predominant isoform in serum but is undetectable in follicular fluid|
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Provided below are standard protocols that you may find useful for product applications.
Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. [provided by RefSeq].
Chen, M.J., et al. Hum. Reprod. 25(3):779-785(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :
Fajardo, M., et al. Clin. Orthop. Relat. Res. 467(12):3071-3078(2009)
Bloise, E., et al. BMC Cancer 9, 320 (2009) :
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