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Mouse Acvr1c Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - Mouse Acvr1c Antibody (C-term) AP14606b
    Mouse Acvr1c Antibody (C-term) (Cat. #AP14606b) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the Acvr1c antibody detected the Acvr1c protein (arrow).
  • SPECIFICATION
  • CITATIONS: 1
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q8K348
Other Accession P70539, Q8NER5, NP_001104500.1
Reactivity Mouse
Predicted Human, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 54700 Da
Antigen Region 341-368 aa
Additional Information
Gene ID 269275
Other Names Activin receptor type-1C, Activin receptor type IC, ACTR-IC, Activin receptor-like kinase 7, ALK-7, Acvr1c {ECO:0000312|EMBL:AAH287801}
Target/Specificity This Mouse Acvr1c antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 341-368 amino acids from the C-terminal region of mouse Acvr1c.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Acvr1c Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Acvr1c {ECO:0000312|EMBL:AAH28780.1}
Function Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Expressed in interdigital regions in developing limb buds.
Research Areas
Citations ( 0 )

Background

Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.

References

Andersson, O., et al. Proc. Natl. Acad. Sci. U.S.A. 105(20):7252-7256(2008)
Bertolino, P., et al. Proc. Natl. Acad. Sci. U.S.A. 105(20):7246-7251(2008)
Liguori, G.L., et al. Dev. Biol. 315(2):280-289(2008)
Kurrasch, D.M., et al. J. Neurosci. 27(50):13624-13634(2007)
Kogame, M., et al. J. Med. Invest. 53 (3-4), 238-245 (2006) :

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$ 295.00
$ 99.00
Cat# AP14606b
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
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