|Application ||WB, E|
|Calculated MW||57345 Da|
|Antigen Region||49-77 aa|
|Other Names||Dual specificity protein kinase CLK4, CDC-like kinase 4, Clk4|
|Target/Specificity||This Mouse Clk4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 49-77 amino acids from the N-terminal region of mouse Clk4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Clk4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.|
|Tissue Location||Expressed in the hippocampus, the cerebellum and the olfactory bulb.|
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Provided below are standard protocols that you may find useful for product applications.
Phosphorylates serine-and arginine-rich (SR) proteins of the spliceosomal complex may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates serines, threonines and tyrosines. Required for the regulation of alternative splicing of MAPT/TAU.
Katsu, R., et al. J. Biol. Chem. 277(46):44220-44228(2002)
Hartmann, A.M., et al. Mol. Cell. Neurosci. 18(1):80-90(2001)
Watkins-Chow, D.E., et al. Genomics 45(1):147-157(1997)
Nayler, O., et al. Biochem. J. 326 (PT 3), 693-700 (1997) :
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