|Application ||WB, E|
|Other Accession||Q9Y463, NP_001033046.1, NP_034222.1|
|Calculated MW||69178 Da|
|Antigen Region||376-403 aa|
|Other Names||Dual specificity tyrosine-phosphorylation-regulated kinase 1B, Dyrk1b|
|Target/Specificity||This Mouse Dyrk1b antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 376-403 amino acids from the Central region of mouse Dyrk1b.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Dyrk1b Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activity. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase (G6PC).|
|Tissue Location||Isoform 1 and isoform 2 are broadly expressed. Isoform 3 seems specific for skeletal muscle (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
Dual-specificity kinase which possesses both serine/ threonine and tyrosine kinase activity. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments.
Janumyan, Y., et al. J. Biol. Chem. 283(49):34108-34120(2008)
Munton, R.P., et al. Mol. Cell Proteomics 6(2):283-293(2007)
Mercer, S.E., et al. J. Biol. Chem. 280(27):25788-25801(2005)
Collins, M.O., et al. J. Biol. Chem. 280(7):5972-5982(2005)
Deng, X., et al. J. Biol. Chem. 280(6):4894-4905(2005)
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