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Mouse Dyrk1b Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9Z188 |
| Other Accession | Q9Y463, NP_001033046.1, NP_034222.1 |
| Reactivity | Mouse |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 69178 Da |
| Antigen Region | 376-403 aa |
| Gene ID | 13549 |
|---|---|
| Other Names | Dual specificity tyrosine-phosphorylation-regulated kinase 1B, Dyrk1b |
| Target/Specificity | This Mouse Dyrk1b antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 376-403 amino acids from the Central region of mouse Dyrk1b. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Dyrk1b Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Dyrk1b |
|---|---|
| Function | Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities (PubMed:12633499). Plays an essential role in ribosomal DNA (rDNA) double-strand break repair and rDNA copy number maintenance. During DNA damage, mediates transcription silencing in part via phosphorylating and enforcing DSB accumulation of the histone methyltransferase EHMT2. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase catalytic subunit 1 (G6PC1). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q9Y463}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9Y463}. Chromosome {ECO:0000250|UniProtKB:Q9Y463}. Note=Localizes to sites of double- strand breaks (DSBs) following DNA damage {ECO:0000250|UniProtKB:Q9Y463} |
| Tissue Location | Isoform 1 and isoform 2 are broadly expressed. Isoform 3 seems specific for skeletal muscle (at protein level) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Dual-specificity kinase which possesses both serine/ threonine and tyrosine kinase activity. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments.
References
Janumyan, Y., et al. J. Biol. Chem. 283(49):34108-34120(2008)
Munton, R.P., et al. Mol. Cell Proteomics 6(2):283-293(2007)
Mercer, S.E., et al. J. Biol. Chem. 280(27):25788-25801(2005)
Collins, M.O., et al. J. Biol. Chem. 280(7):5972-5982(2005)
Deng, X., et al. J. Biol. Chem. 280(6):4894-4905(2005)
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