|Application ||WB, E|
|Other Accession||P36888, NP_034359.2|
|Calculated MW||113496 Da|
|Antigen Region||154-181 aa|
|Other Names||Receptor-type tyrosine-protein kinase FLT3, FL cytokine receptor, Fetal liver kinase 2, FLK-2, Fms-like tyrosine kinase 3, FLT-3, Tyrosine-protein kinase receptor flk-2, CD135, Flt3, Flk-2, Flt-3|
|Target/Specificity||This Mouse Flt3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 154-181 amino acids from the N-terminal region of mouse Flt3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Flt3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.|
|Cellular Location||Membrane; Single-pass type I membrane protein. Endoplasmic reticulum lumen Note=Constitutively activated mutant forms with internal tandem duplications are less efficiently transported to the cell surface and a significant proportion is retained in an immature form in the endoplasmic reticulum lumen. The activated kinase is rapidly targeted for degradation (By similarity).|
|Tissue Location||Hematopoietic stem and progenitor cell- enriched populations. Found in brain, placenta and testis|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Flt3 is a receptor for the FL cytokine. Has a tyrosine-protein kinase activity.
Rathinam, C., et al. Cancer Cell 18(4):341-352(2010)
DeBoy, C.A., et al. Exp. Mol. Pathol. 89(2):109-116(2010)
Mkonyi, L.E., et al. Am. J. Physiol. Heart Circ. Physiol. 299 (2), H275-H283 (2010) :
Carotta, S., et al. Immunity 32(5):628-641(2010)
Eidenschenk, C., et al. Proc. Natl. Acad. Sci. U.S.A. 107(21):9759-9764(2010)
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