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Mouse Flt3 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - Mouse Flt3 Antibody (N-term) AP14621A
    Mouse Flt3 Antibody (N-term) (Cat. #AP14621a) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the Flt3 antibody detected the Flt3 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q00342
Other Accession P36888, NP_034359.2
Reactivity Mouse
Predicted Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 113496 Da
Antigen Region 154-181 aa
Additional Information
Gene ID 14255
Other Names Receptor-type tyrosine-protein kinase FLT3, FL cytokine receptor, Fetal liver kinase 2, FLK-2, Fms-like tyrosine kinase 3, FLT-3, Tyrosine-protein kinase receptor flk-2, CD135, Flt3, Flk-2, Flt-3
Target/Specificity This Mouse Flt3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 154-181 amino acids from the N-terminal region of mouse Flt3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Flt3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Flt3
Synonyms Flk-2, Flt-3
Function Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.
Cellular Location Membrane; Single-pass type I membrane protein. Endoplasmic reticulum lumen Note=Constitutively activated mutant forms with internal tandem duplications are less efficiently transported to the cell surface and a significant proportion is retained in an immature form in the endoplasmic reticulum lumen. The activated kinase is rapidly targeted for degradation (By similarity).
Tissue Location Hematopoietic stem and progenitor cell- enriched populations. Found in brain, placenta and testis
Research Areas
Citations (0)

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Flt3 is a receptor for the FL cytokine. Has a tyrosine-protein kinase activity.


Rathinam, C., et al. Cancer Cell 18(4):341-352(2010)
DeBoy, C.A., et al. Exp. Mol. Pathol. 89(2):109-116(2010)
Mkonyi, L.E., et al. Am. J. Physiol. Heart Circ. Physiol. 299 (2), H275-H283 (2010) :
Carotta, S., et al. Immunity 32(5):628-641(2010)
Eidenschenk, C., et al. Proc. Natl. Acad. Sci. U.S.A. 107(21):9759-9764(2010)

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$ 295.00
$ 99.00
Cat# AP14621A
(40 western blots)
Availability: In Stock
Bulk Size
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