|Application ||WB, IHC-P, E|
|Other Accession||Q03351, NP_032772.3, NP_877961.1|
|Calculated MW||92760 Da|
|Antigen Region||161-188 aa|
|Other Names||NT-3 growth factor receptor, GP145-TrkC, Trk-C, Neurotrophic tyrosine kinase receptor type 3, TrkC tyrosine kinase, Ntrk3, TrkC|
|Target/Specificity||This Mouse Ntrk3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 161-188 amino acids from the N-terminal region of mouse Ntrk3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Ntrk3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Isoform 2 expression is restricted to specific areas in adult brain. Isoform 3 transcripts are readily detected early during embryogenesis and are expressed predominantly in adult brain and gonads.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Ntrk3 is a receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1 (By similarity).
Gascon, E., et al. J. Neurosci. 30(37):12414-12423(2010)
Nikoletopoulou, V., et al. Nature 467(7311):59-63(2010)
Honma, Y., et al. Development 137(14):2319-2328(2010)
Huang, T., et al. J Mol Cell Biol 2(3):152-163(2010)
Li, W., et al. BMC Biol. 8, 86 (2010) :
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