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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Mouse Ksr2 Antibody (C-term)   

Mouse Ksr2 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - Mouse Ksr2 Antibody (C-term) AP14634b
    Mouse Ksr2 Antibody (C-term) (Cat. #AP14634b) western blot analysis in human normal Uterus tissue lysates (35ug/lane).This demonstrates the Ksr2 antibody detected the Ksr2 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q3UVC0
Other Accession NP_001030045.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 108572 Da
Antigen Region 808-836 aa
Additional Information
Other Names Kinase suppressor of Ras 2, Ksr2 {ECO:0000312|MGI:MGI:3610315}
Target/Specificity This Mouse Ksr2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 808-836 amino acids from the C-terminal region of mouse Ksr2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Ksr2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Ksr2 {ECO:0000312|MGI:MGI:3610315}
Function Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8- mediated signaling. Acts as a negative regulator of MAP3K3- mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production (By similarity).
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:Q61097}. Membrane {ECO:0000250|UniProtKB:Q61097}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q61097}
Research Areas
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Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production (By similarity).


Costanzo-Garvey, D.L., et al. Cell Metab. 10(5):366-378(2009) Dougherty, M.K., et al. Mol. Cell 34(6):652-662(2009)

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$ 295.00
$ 99.00
Cat# AP14634b
(40 western blots)
Availability: In Stock
Bulk Size
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