|Application ||WB, E|
|Calculated MW||111906 Da|
|Antigen Region||668-696 aa|
|Other Names||Serine/threonine-protein kinase 10, Lymphocyte-oriented kinase, Stk10, Lok|
|Target/Specificity||This Mouse Stk10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 668-696 amino acids from the C-terminal region of mouse Stk10.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Stk10 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo.|
|Cellular Location||Cell membrane; Peripheral membrane protein|
|Tissue Location||Expressed predominantly in lymphoid organs such as spleen, thymus, and bone marrow|
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Provided below are standard protocols that you may find useful for product applications.
Stk10 can act on substrates such as myelin basic protein and histone 2A on serine and threonine residues.
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