|Application ||WB, E|
|Primary Accession||Q91Y86 and P45983|
|Other Accession||Q8QHK8, P49185, NP_057909.1, P45983, Q91Y86|
|Predicted||Mouse, Rat, Xenopus|
|Antigen Region||239-268 aa|
|Other Names||Mitogen-activated protein kinase 8, MAP kinase 8, MAPK 8, Stress-activated protein kinase JNK1, c-Jun N-terminal kinase 1, Mapk8, Jnk1, Prkm8|
|Target/Specificity||This Mouse Mapk8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 239-268 amino acids from the Central region of mouse Mapk8.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Mapk8 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Mapk8 responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. Phosphorylates heat shock factor protein 4 (HSF4) (By similarity).
Sherrin, T., et al. J. Neurosci. 30(40):13348-13361(2010)
Morel, C., et al. Mol. Cell. Biol. 30(19):4616-4625(2010)
Gao, D., et al. J. Biol. Chem. 285(39):29965-29973(2010)
Han, J.S., et al. Anticancer Res. 30(9):3407-3412(2010)
Cellurale, C., et al. PLoS ONE 5 (8), E12469 (2010) :
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