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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   LRP5 Antibody (C-term)   

LRP5 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - LRP5 Antibody (C-term) AP14655b
    LRP5 Antibody (C-term) (Cat. #AP14655b) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the LRP5 antibody detected the LRP5 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O75197
Other Accession Q91VN0, NP_002326.2
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 179145 Da
Antigen Region 1163-1190 aa
Additional Information
Gene ID 4041
Other Names Low-density lipoprotein receptor-related protein 5, LRP-5, LRP5, LR3, LRP7
Target/Specificity This LRP5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1163-1190 amino acids from the C-terminal region of human LRP5.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLRP5 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LRP5
Synonyms LR3, LRP7
Function Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3- mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation.
Cellular Location Membrane; Single-pass type I membrane protein. Endoplasmic reticulum. Note=Chaperoned to the plasma membrane by MESD.
Tissue Location Widely expressed, with the highest level of expression in the liver and in aorta
Research Areas
Citations (0)

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This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy.


Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Lee, D.Y., et al. Menopause 17(5):1064-1070(2010)
Liu, J.M., et al. J. Clin. Endocrinol. Metab. 95 (9), E112-E120 (2010) :
Paternoster, L., et al. J. Clin. Endocrinol. Metab. 95(8):3940-3948(2010)
Stathopoulou, M.G., et al. J Am Diet Assoc 110(7):1078-1083(2010)

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$ 295.00
$ 99.00
Cat# AP14655b
(40 western blots)
Availability: In Stock
Bulk Size
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