|Application ||WB, IHC-P, E|
|Other Accession||P63025, P63024, Q4R8T0, Q2KJD2, P63045, P63044, P63027, P63026, Q63666, Q62442, P23763, Q0V7N0, NP_004772.1|
|Reactivity||Human, Mouse, Zebrafish|
|Predicted||Bovine, Rat, Monkey|
|Calculated MW||11309 Da|
|Antigen Region||15-43 aa|
|Other Names||Vesicle-associated membrane protein 3, VAMP-3, Cellubrevin, CEB, Synaptobrevin-3, VAMP3, SYB3|
|Target/Specificity||This VAMP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-43 amino acids from the Central region of human VAMP3.|
|Precautions||VAMP3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.|
|Cellular Location||Membrane; Single-pass type IV membrane protein. Cell junction, synapse, synaptosome|
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Provided below are standard protocols that you may find useful for product applications.
Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation.
Ban, H.J., et al. BMC Genet. 11, 26 (2010) :
Fader, C.M., et al. Biochim. Biophys. Acta 1793(12):1901-1916(2009)
Kean, M.J., et al. J. Cell. Sci. 122 (PT 22), 4089-4098 (2009) :
Vassilopoulos, S., et al. Science 324(5931):1192-1196(2009)
Luftman, K., et al. Biochem. Biophys. Res. Commun. 380(1):65-70(2009)
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