|Application ||WB, IHC-P, E|
|Other Accession||NP_073626.1, NP_758525.1|
|Calculated MW||20330 Da|
|Antigen Region||76-104 aa|
|Other Names||Interleukin-25, IL-25, Interleukin-17E, IL-17E, IL25, IL17E|
|Target/Specificity||This IL25 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 76-104 amino acids from the Central region of human IL25.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IL25 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses.|
|Tissue Location||Expressed at low levels in several tissues, including brain, kidney, lung, prostate, testis, spinal cord, adrenal gland, and trachea|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. Studies of a similar gene in mice suggest that this cytokine may be a pro-inflammatory cytokine favoring the Th2-type immune response. Alternative splicing results in multiple transcript variants.
Xu, G., et al. Allergy 65(5):581-589(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Goswami, S., et al. Nat. Immunol. 10(5):496-503(2009)
Caruso, R., et al. Blood 113(15):3512-3519(2009)
Garley, M., et al. Adv Med Sci 53(2):326-330(2008)
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