|Application ||WB, IHC-P, E|
|Other Accession||NP_073626.1, NP_758525.1|
|Calculated MW||20330 Da|
|Antigen Region||76-104 aa|
|Other Names||Interleukin-25, IL-25, Interleukin-17E, IL-17E, IL25, IL17E|
|Target/Specificity||This IL25 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 76-104 amino acids from the Central region of human IL25.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IL25 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses.|
|Tissue Location||Expressed at low levels in several tissues, including brain, kidney, lung, prostate, testis, spinal cord, adrenal gland, and trachea|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. Studies of a similar gene in mice suggest that this cytokine may be a pro-inflammatory cytokine favoring the Th2-type immune response. Alternative splicing results in multiple transcript variants.
Xu, G., et al. Allergy 65(5):581-589(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Goswami, S., et al. Nat. Immunol. 10(5):496-503(2009)
Caruso, R., et al. Blood 113(15):3512-3519(2009)
Garley, M., et al. Adv Med Sci 53(2):326-330(2008)
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