|Application ||WB, E|
|Other Accession||Q0V8L6, NP_002654.3|
|Calculated MW||105987 Da|
|Antigen Region||10-39 aa|
|Other Names||Phospholipase D2, PLD 2, hPLD2, Choline phosphatase 2, PLD1C, Phosphatidylcholine-hydrolyzing phospholipase D2, PLD2|
|Target/Specificity||This PLD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 10-39 amino acids from the N-terminal region of human PLD2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PLD2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May have a role in signal-induced cytoskeletal regulation and/or endocytosis.|
|Cellular Location||Membrane; Peripheral membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Phosphatidylcholine (PC)-specific phospholipases D (PLDs; EC 184.108.40.206) catalyze the hydrolysis of PC to produce phosphatidic acid and choline. Activation of PC-specific PLDs occurs as a consequence of agonist stimulation of both tyrosine kinase and G protein-coupled receptors. PC-specific PLDs have been proposed to function in regulated secretion, cytoskeletal reorganization, transcriptional regulation, and cell cycle control.[supplied by OMIM].
Chae, Y.C., et al. Mol. Cell. Biol. 30(21):5086-5098(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Knapek, K., et al. Mol. Cell. Biol. 30(18):4492-4506(2010)
Tabatabaian, F., et al. J. Biol. Chem. 285(25):18991-19001(2010)
Kang, D.W., et al. PLoS ONE 5 (8), E12109 (2010) :
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