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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   FBLN1 Antibody (C-term)   

FBLN1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - FBLN1 Antibody (C-term) AP14671b
    FBLN1 Antibody (C-term) (Cat. #AP14671b) western blot analysis in mouse cerebellum tissue lysates (35ug/lane).This demonstrates the FBLN1 antibody detected the FBLN1 protein (arrow).
  • WB - FBLN1 Antibody (C-term) AP14671b
    FBLN1 Antibody (C-term) (Cat. #AP14671b) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the FBLN1 antibody detected the FBLN1 protein (arrow).
  • IHC-P - FBLN1 Antibody (C-term) AP14671b
    FBLN1 Antibody (C-term) (AP14671b)immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of FBLN1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P23142
Other Accession Q08879, NP_001987.2, NP_006477.2
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 77214 Da
Antigen Region 622-650 aa
Additional Information
Gene ID 2192
Other Names Fibulin-1, FIBL-1, FBLN1
Target/Specificity This FBLN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 622-650 amino acids from the C-terminal region of human FBLN1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFBLN1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FBLN1
Function Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP.
Cellular Location Secreted, extracellular space, extracellular matrix
Tissue Location Isoform A and isoform B are only expressed in placenta. Isoform C and isoform D are expressed in a variety of tissues and cultured cells.
Research Areas
Citations (0)

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Fibulin 1 is a secreted glycoprotein that becomes incorporated into a fibrillar extracellular matrix. Calcium-binding is apparently required to mediate its binding to laminin and nidogen. It mediates platelet adhesion via binding fibrinogen. Four splice variants which differ in the 3' end have been identified. Each variant encodes a different isoform, but no functional distinctions have been identified among the four variants.


Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Li, C., et al. Mol. Vis. 16, 689-697 (2010) :
Wooten, E.C., et al. PLoS ONE 5 (1), E8830 (2010) :
Argraves, W.S., et al. Histochem. Cell Biol. 132(5):559-565(2009)
Piscaglia, F., et al. Cell Tissue Res. 337(3):449-462(2009)

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Cat# AP14671b
(40 western blots)
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