|Application ||WB, E|
|Calculated MW||107533 Da|
|Antigen Region||8-36 aa|
|Other Names||Desmoglein-3, 130 kDa pemphigus vulgaris antigen, PVA, Cadherin family member 6, DSG3, CDHF6|
|Target/Specificity||This DSG3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8-36 amino acids from the N-terminal region of human DSG3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DSG3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome|
|Tissue Location||Epidermis, tongue, tonsil, esophagus and carcinomas|
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Provided below are standard protocols that you may find useful for product applications.
Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris.
Baican, A., et al. Int. J. Dermatol. 49(7):768-774(2010)
Jolly, P.S., et al. J. Biol. Chem. 285(12):8936-8941(2010)
Capon, F., et al. Br. J. Dermatol. 161(6):1403-1405(2009)
Aoyama, Y., et al. Exp. Dermatol. 18(4):404-408(2009)
Latourelle, J.C., et al. BMC Med. Genet. 10, 98 (2009) :
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