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APLP2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q06481 |
| Other Accession | NP_001135748.1, NP_001633.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 86956 Da |
| Antigen Region | 593-621 aa |
| Gene ID | 334 |
|---|---|
| Other Names | Amyloid-like protein 2, APLP-2, APPH, Amyloid protein homolog, CDEI box-binding protein, CDEBP, APLP2, APPL2 |
| Target/Specificity | This APLP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 593-621 amino acids from the C-terminal region of human APLP2. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | APLP2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | APLP2 (HGNC:598) |
|---|---|
| Function | May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Nucleus |
| Tissue Location | Expressed in placenta, brain, heart, lung, liver, kidney and endothelial tissues |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
APLP2 may play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Tuli, A., et al. J. Biol. Chem. 284(49):34296-34307(2009)
Kaden, D., et al. J. Cell. Sci. 122 (PT 3), 368-377 (2009) :
Tuli, A., et al. J. Immunol. 181(3):1978-1987(2008)
Tuli, A., et al. Immunogenetics 60(6):303-313(2008)
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