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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   APLP2 Antibody (C-term)   

APLP2 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - APLP2 Antibody (C-term) AP14673b
    APLP2 Antibody (C-term) (Cat. #AP14673b) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the APLP2 antibody detected the APLP2 protein (arrow).
  • WB - APLP2 Antibody (C-term) AP14673b
    APLP2 Antibody (C-term) (Cat. #AP14673b) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the APLP2 antibody detected the APLP2 protein (arrow).
  • IHC-P - APLP2 Antibody (C-term) AP14673b
    APLP2 Antibody (C-term) (AP14673b)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of APLP2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q06481
Other Accession NP_001135748.1, NP_001633.1
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 86956 Da
Antigen Region 593-621 aa
Additional Information
Gene ID 334
Other Names Amyloid-like protein 2, APLP-2, APPH, Amyloid protein homolog, CDEI box-binding protein, CDEBP, APLP2, APPL2
Target/Specificity This APLP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 593-621 amino acids from the C-terminal region of human APLP2.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAPLP2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name APLP2
Synonyms APPL2
Function May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity).
Cellular Location Cell membrane; Single-pass type I membrane protein. Nucleus
Tissue Location Expressed in placenta, brain, heart, lung, liver, kidney and endothelial tissues
Research Areas
Citations (0)

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Background

APLP2 may play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein.

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Tuli, A., et al. J. Biol. Chem. 284(49):34296-34307(2009)
Kaden, D., et al. J. Cell. Sci. 122 (PT 3), 368-377 (2009) :
Tuli, A., et al. J. Immunol. 181(3):1978-1987(2008)
Tuli, A., et al. Immunogenetics 60(6):303-313(2008)

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Discontinued
Cat# AP14673b
Size:
(40 western blots)
Alternative Products:

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