|Application ||WB, IHC-P, E|
|Other Accession||NP_001135748.1, NP_001633.1|
|Calculated MW||86956 Da|
|Antigen Region||593-621 aa|
|Other Names||Amyloid-like protein 2, APLP-2, APPH, Amyloid protein homolog, CDEI box-binding protein, CDEBP, APLP2, APPL2|
|Target/Specificity||This APLP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 593-621 amino acids from the C-terminal region of human APLP2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||APLP2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Nucleus|
|Tissue Location||Expressed in placenta, brain, heart, lung, liver, kidney and endothelial tissues|
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Provided below are standard protocols that you may find useful for product applications.
APLP2 may play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Tuli, A., et al. J. Biol. Chem. 284(49):34296-34307(2009)
Kaden, D., et al. J. Cell. Sci. 122 (PT 3), 368-377 (2009) :
Tuli, A., et al. J. Immunol. 181(3):1978-1987(2008)
Tuli, A., et al. Immunogenetics 60(6):303-313(2008)
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