|Application ||WB, IHC-P, E|
|Other Accession||Q64122, P29269, Q9CQ19, P02612, NP_006088.2|
|Predicted||Chicken, Mouse, Pig, Rat|
|Calculated MW||19827 Da|
|Antigen Region||96-125 aa|
|Other Names||Myosin regulatory light polypeptide 9, 20 kDa myosin light chain, LC20, MLC-2C, Myosin RLC, Myosin regulatory light chain 2, smooth muscle isoform, Myosin regulatory light chain 9, Myosin regulatory light chain MRLC1, MYL9, MLC2, MRLC1, MYRL2|
|Target/Specificity||This MYL9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 96-125 amino acids from the C-terminal region of human MYL9.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MYL9 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||MLC2, MRLC1, MYRL2|
|Function||Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion.|
|Tissue Location||Smooth muscle tissues and in some, but not all, nonmuscle cells|
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Provided below are standard protocols that you may find useful for product applications.
Myosin, a structural component of muscle, consists of two heavy chains and four light chains. The protein encoded by this gene is a myosin light chain that may regulate muscle contraction by modulating the ATPase activity of myosin heads. The encoded protein binds calcium and is activated by myosin light chain kinase. Two transcript variants encoding different isoforms have been found for this gene.
Gilles, L., et al. Blood 114(19):4221-4232(2009)
Higashihara, M., et al. J Smooth Muscle Res 44(1):29-40(2008)
Szczesna-Cordary, D., et al. J. Cell. Sci. 118 (PT 16), 3675-3683 (2005) :
Webb, R.C. Adv Physiol Educ 27 (1-4), 201-206 (2003) :
Deloukas, P., et al. Nature 414(6866):865-871(2001)
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