|Application ||WB, E|
|Other Accession||Q03356, P70354, P52953, Q03358, P28362, Q0P5C3, P13297, P28360, P28361, O02786, P35993, P50223, NP_002440.2|
|Predicted||Chicken, Xenopus, Bovine, Mouse, Rat, Zebrafish|
|Calculated MW||28897 Da|
|Antigen Region||120-148 aa|
|Other Names||Homeobox protein MSX-2, Homeobox protein Hox-8, MSX2, HOX8|
|Target/Specificity||This MSX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 120-148 amino acids from the Central region of human MSX2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MSX2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the muscle segment homeobox gene family. The encoded protein is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. The encoded protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in this gene are associated with parietal foramina 1 and craniosynostosis type 2.
Nikopensius, T., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 88(9):748-756(2010)
Satoh, K., et al. J. Gastroenterol. 45(7):763-770(2010)
Doi, T., et al. J. Pediatr. Surg. 45(6):1187-1191(2010)
Jagomagi, T., et al. Eur. J. Oral Sci. 118(3):213-220(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
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