|Application ||WB, E|
|Calculated MW||33275 Da|
|Antigen Region||261-290 aa|
|Other Names||Programmed cell death 1 ligand 1, PD-L1, PDCD1 ligand 1, Programmed death ligand 1, B7 homolog 1, B7-H1, CD274, CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1|
|Target/Specificity||This CD274 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 261-290 amino acids from the C-terminal region of human CD274.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD274 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||B7H1, PDCD1L1, PDCD1LG1, PDL1|
|Function||Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.|
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Provided below are standard protocols that you may find useful for product applications.
Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.
Berthon, C., et al. Cancer Immunol. Immunother. 59(12):1839-1849(2010)
Dianzani, C., et al. J. Immunol. 185(7):3970-3979(2010)
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Alvarez, I.B., et al. J. Infect. Dis. 202(4):524-532(2010)
Francisco, L.M., et al. Immunol. Rev. 236, 219-242 (2010) :
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