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TRA2B Antibody (Center)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP14688c | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP14688c-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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- Citiations : 0
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- Backgrounds
TRA2B Antibody (Center) - Product info | |
| Application | WB, IHC
|
| Primary Accession | P62995 |
| Other Accession | P62997, P62996, Q3ZBT6, NP_004584.1 |
| Reactivity | Human |
| Predicted | Bovine, Mouse, Rat |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 33666 Da |
TRA2B Antibody (Center) - Additional info | |
| Gene ID 6434 | |
| Other Names TRA2B; SFRS10; Transformer-2 protein homolog beta; Splicing factor, arginine/serine-rich 10; Transformer-2 protein homolog B | |
| Target/Specificity This TRA2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 207-237 amino acids from the Central region of human TRA2B. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions TRA2B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. | |
TRA2B Antibody (Center) - Protein Information | |
| Name TRA2B | |
| Synonyms SFRS10 | |
| Function Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre- mRNA | |
| Cellular Location Nucleus. | |
| Tissue Location Highest expression in heart, skeletal muscle and pancreas. Less abundant in kidney, placenta and brain. Lowest expression in kidney and liver | |
TRA2B Antibody (Center) - Related products
AP14688c: TRA2B Antibody (Center)
TRA2B Antibody (Center) - Application data
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TRA2B Antibody (Center) (Cat. #AP14688c) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the TRA2B antibody detected the TRA2B protein (arrow).
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TRA2B Antibody (Center) (AP14688c)immunohistochemistry analysis in formalin fixed and paraffin embedded human cerebellum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TRA2B Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
TRA2B Antibody (Center) - Research Areas
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BACKGROUND
TRA2B is a sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing.
REFERENCES
Benderska, N., et al. Biochim. Biophys. Acta 1799 (5-6), 448-453 (2010) : Thorleifsson, G., et al. Nat. Genet. 41(1):18-24(2009) Caporaso, N., et al. PLoS ONE 4 (2), E4653 (2009) : Gabriel, B., et al. Acta Obstet Gynecol Scand 88(2):216-221(2009) Miele, A., et al. J. Cell. Biochem. 102(1):136-148(2007)
