|Application ||WB, IHC-P, E|
|Other Accession||P62997, P62996, Q3ZBT6, NP_004584.1|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||33666 Da|
|Antigen Region||208-237 aa|
|Other Names||Transformer-2 protein homolog beta, TRA-2 beta, TRA2-beta, hTRA2-beta, Splicing factor, arginine/serine-rich 10, Transformer-2 protein homolog B, TRA2B, SFRS10|
|Target/Specificity||This TRA2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 208-237 amino acids from the Central region of human TRA2B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TRA2B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre- mRNA.|
|Tissue Location||Highest expression in heart, skeletal muscle and pancreas. Less abundant in kidney, placenta and brain. Lowest expression in kidney and liver.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
TRA2B is a sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing.
Benderska, N., et al. Biochim. Biophys. Acta 1799 (5-6), 448-453 (2010) :
Thorleifsson, G., et al. Nat. Genet. 41(1):18-24(2009)
Caporaso, N., et al. PLoS ONE 4 (2), E4653 (2009) :
Gabriel, B., et al. Acta Obstet Gynecol Scand 88(2):216-221(2009)
Miele, A., et al. J. Cell. Biochem. 102(1):136-148(2007)
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