|Application ||WB, IHC-P, E|
|Other Accession||P62997, P62996, Q3ZBT6, NP_004584.1|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||33666 Da|
|Antigen Region||208-237 aa|
|Other Names||Transformer-2 protein homolog beta, TRA-2 beta, TRA2-beta, hTRA2-beta, Splicing factor, arginine/serine-rich 10, Transformer-2 protein homolog B, TRA2B, SFRS10|
|Target/Specificity||This TRA2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 208-237 amino acids from the Central region of human TRA2B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TRA2B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre- mRNA.|
|Tissue Location||Highest expression in heart, skeletal muscle and pancreas. Less abundant in kidney, placenta and brain. Lowest expression in kidney and liver.|
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Provided below are standard protocols that you may find useful for product applications.
TRA2B is a sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing.
Benderska, N., et al. Biochim. Biophys. Acta 1799 (5-6), 448-453 (2010) :
Thorleifsson, G., et al. Nat. Genet. 41(1):18-24(2009)
Caporaso, N., et al. PLoS ONE 4 (2), E4653 (2009) :
Gabriel, B., et al. Acta Obstet Gynecol Scand 88(2):216-221(2009)
Miele, A., et al. J. Cell. Biochem. 102(1):136-148(2007)
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