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TRA2B Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - TRA2B Antibody (Center) AP14688c
    TRA2B Antibody (Center) (Cat. #AP14688c) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the TRA2B antibody detected the TRA2B protein (arrow).
  • IHC-P - TRA2B Antibody (Center) AP14688c
    TRA2B Antibody (Center) (AP14688c)immunohistochemistry analysis in formalin fixed and paraffin embedded human cerebellum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TRA2B Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P62995
Other Accession P62997, P62996, Q3ZBT6, NP_004584.1
Reactivity Human
Predicted Bovine, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 33666 Da
Antigen Region 208-237 aa
Additional Information
Gene ID 6434
Other Names Transformer-2 protein homolog beta, TRA-2 beta, TRA2-beta, hTRA2-beta, Splicing factor, arginine/serine-rich 10, Transformer-2 protein homolog B, TRA2B, SFRS10
Target/Specificity This TRA2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 208-237 amino acids from the Central region of human TRA2B.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTRA2B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRA2B
Synonyms SFRS10
Function Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre- mRNA.
Cellular Location Nucleus
Tissue Location Highest expression in heart, skeletal muscle and pancreas. Less abundant in kidney, placenta and brain. Lowest expression in kidney and liver.
Citations (0)

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TRA2B is a sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing.


Benderska, N., et al. Biochim. Biophys. Acta 1799 (5-6), 448-453 (2010) :
Thorleifsson, G., et al. Nat. Genet. 41(1):18-24(2009)
Caporaso, N., et al. PLoS ONE 4 (2), E4653 (2009) :
Gabriel, B., et al. Acta Obstet Gynecol Scand 88(2):216-221(2009)
Miele, A., et al. J. Cell. Biochem. 102(1):136-148(2007)

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$ 295.00
$ 99.00
Cat# AP14688c
(40 western blots)
Availability: In Stock
Bulk Size
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