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Mouse Prkcg Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P63318 |
| Other Accession | P63319, P10829, Q4R4U2, P05129, P05128, NP_035232.1 |
| Reactivity | Mouse |
| Predicted | Bovine, Human, Monkey, Rabbit, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 78358 Da |
| Antigen Region | 74-102 aa |
| Gene ID | 18752 |
|---|---|
| Other Names | Protein kinase C gamma type, PKC-gamma, Prkcg, Pkcc, Pkcg, Prkcc |
| Target/Specificity | This Mouse Prkcg antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 74-102 amino acids from the N-terminal region of mouse Prkcg. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Prkcg Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Prkcg |
|---|---|
| Synonyms | Pkcc, Pkcg, Prkcc |
| Function | Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5- dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contribute to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress. Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage. Involved in the phase resetting of the cerebral cortex circadian clock during temporally restricted feeding. Stabilizes the core clock component BMAL1 by interfering with its ubiquitination, thus suppressing its degradation, resulting in phase resetting of the cerebral cortex clock (PubMed:23185022). |
| Cellular Location | Cytoplasm. Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein. Synapse, synaptosome Cell projection, dendrite {ECO:0000250|UniProtKB:P63319} Note=Translocates to synaptic membranes on stimulation |
| Tissue Location | Expressed in the cerebellum, cerebral cortex and hippocampus (at protein level). Highly expressed in Purkinje cells |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
This is a calcium-activated, phospholipid-dependent, serine-and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.
References
Seki, T., et al. J. Biol. Chem. 285(43):33252-33264(2010)
Deng, P.Y., et al. J. Neurosci. 30(15):5136-5148(2010)
Ross, S.E., et al. Neuron 65(6):886-898(2010)
Brzezinski, J.A. IV, et al. Development 137(4):619-629(2010)
Tao, H., et al. Proc. Natl. Acad. Sci. U.S.A. 106(34):14426-14431(2009)
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$ 365.00
$ 140.00
Cat# AP14698a
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