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ALDH6A1 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - ALDH6A1 Antibody (N-term) AP1469a
    Anti-ALDH6A1 Antibody (N-term) at 1:1000 dilution + human liver lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 58 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - ALDH6A1 Antibody (N-term) AP1469a
    Anti-ALDH6A1 Antibody (N-term) at 1:1000 dilution + human liver lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 58 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - ALDH6A1 Antibody (N-term) AP1469a
    Western blot analysis of ALDH6A1 Antibody (N-term) (Cat.#AP1469a) in T47D cell line lysates (35ug/lane). ALDH6A1 (arrow) was detected using the purified Pab.
  • IHC-P - ALDH6A1 Antibody (N-term) AP1469a
    Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with *ALDH6A1 antibody (N-term) (Cat.#AP1469a), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • FC - ALDH6A1 Antibody (N-term) AP1469a
    Flow cytometric analysis of ATDC5 cells using ALDH6A1 Antibody (N-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, FC, IHC-P, E
Primary Accession Q02252
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 57840 Da
Antigen Region 30-59 aa
Additional Information
Gene ID 4329
Other Names Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial, MMSDH, Malonate-semialdehyde dehydrogenase [acylating], Aldehyde dehydrogenase family 6 member A1, ALDH6A1, MMSDH
Target/Specificity This ALDH6A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 30-59 amino acids from the N-terminal region of human ALDH6A1.
Dilution WB~~1:1000
IHC-P~~1:10~50
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsALDH6A1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ALDH6A1
Synonyms MMSDH
Function Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.
Cellular Location Mitochondrion.
Research Areas
Citations (0)

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Background

ALDH6A1 belongs to the aldehyde dehydrogenases family of proteins. This enzyme plays a role in the valine and pyrimidine catabolic pathways. This protein is a mitochondrial methylmalonate semialdehyde dehydrogenase, and catalyzes the irreversible oxidative decarboxylation of malonate and methylmalonate semialdehydes to acetyl- and propionyl-CoA. Methylmalonate semialdehyde dehydrogenase deficiency is characterized by elevated beta-alanine, 3-hydroxypropionic acid, and both isomers of 3-amino and 3-hydroxyisobutyric acids in urine organic acids.

References

Kuiper,H., Cytogenet. Genome Res. 109 (4), 533 (2005)
Anderson,N.L., Mol. Cell Proteomics 3 (4), 311-326 (2004)
Chambliss,K.L., J. Inherit. Metab. Dis. 23 (5), 497-504 (2000)
Kedishvili,N.Y., J. Biol. Chem. 267 (27), 19724-19729 (1992)

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$ 295.00
$ 99.00
Cat# AP1469a
Size:
Quantity:
(40 western blots)
Availability: In Stock
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