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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Mouse Csnk1e Antibody (C-term)   

Mouse Csnk1e Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - Mouse Csnk1e Antibody (C-term) AP14708b
    Mouse Csnk1e Antibody (C-term) (Cat. #AP14708b) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the Csnk1e antibody detected the Csnk1e protein (arrow).
  • IHC-P - Mouse Csnk1e Antibody (C-term) AP14708b
    Mouse Csnk1e Antibody (C-term) (AP14708b)immunohistochemistry analysis in formalin fixed and paraffin embedded mouse live tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Mouse Csnk1e Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9JMK2
Other Accession P49674, NP_038795.3
Reactivity Mouse
Predicted Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 47322 Da
Antigen Region 283-310 aa
Additional Information
Gene ID 27373
Other Names Casein kinase I isoform epsilon, CKI-epsilon, CKIe, Csnk1e
Target/Specificity This Mouse Csnk1e antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 283-310 amino acids from the C-terminal region of mouse Csnk1e.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Csnk1e Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Csnk1e
Function Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine- induced granuloytic differentiation.
Cellular Location Cytoplasm. Nucleus
Tissue Location Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. Expressed in monocytes and lymphocytes but not in granulocytes.
Research Areas
Citations (0)

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Background

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm. Inhibits cytokine-induced granuloytic differentiation.

References

Meng, Q.J., et al. Proc. Natl. Acad. Sci. U.S.A. 107(34):15240-15245(2010)
Sugiyama, Y., et al. Biochem. J. 427(3):489-497(2010)
Etchegaray, J.P., et al. PLoS ONE 5 (4), E10303 (2010) :
Lee, H., et al. Proc. Natl. Acad. Sci. U.S.A. 106(50):21359-21364(2009)
Isojima, Y., et al. Proc. Natl. Acad. Sci. U.S.A. 106(37):15744-15749(2009)

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$ 295.00
$ 99.00
Cat# AP14708b
Size:
Quantity:
(40 western blots)
Availability: In Stock
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