|Application ||WB, IHC-P, E|
|Other Accession||P49674, NP_038795.3|
|Calculated MW||47322 Da|
|Antigen Region||283-310 aa|
|Other Names||Casein kinase I isoform epsilon, CKI-epsilon, CKIe, Csnk1e|
|Target/Specificity||This Mouse Csnk1e antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 283-310 amino acids from the C-terminal region of mouse Csnk1e.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Csnk1e Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phospohorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine- induced granuloytic differentiation.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. Expressed in monocytes and lymphocytes but not in granulocytes.|
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Provided below are standard protocols that you may find useful for product applications.
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm. Inhibits cytokine-induced granuloytic differentiation.
Meng, Q.J., et al. Proc. Natl. Acad. Sci. U.S.A. 107(34):15240-15245(2010)
Sugiyama, Y., et al. Biochem. J. 427(3):489-497(2010)
Etchegaray, J.P., et al. PLoS ONE 5 (4), E10303 (2010) :
Lee, H., et al. Proc. Natl. Acad. Sci. U.S.A. 106(50):21359-21364(2009)
Isojima, Y., et al. Proc. Natl. Acad. Sci. U.S.A. 106(37):15744-15749(2009)
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