|Application ||WB, E|
|Other Accession||Q9UIK4, NP_034149.2|
|Calculated MW||42778 Da|
|Antigen Region||38-65 aa|
|Other Names||Death-associated protein kinase 2, DAP kinase 2, DAP-kinase-related protein 1, DRP-1, Dapk2|
|Target/Specificity||This Mouse Dapk2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-65 amino acids from the N-terminal region of mouse Dapk2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Dapk2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Capable of regulating both type I apoptotic and type II autophagic cell death signals. The former involves caspase activation, chromatin and mitochondrial condensation while the latter involves caspase-independent cell death in conjunction with accumulation of mature autophagic vesicles, plasma membrane blebs, and nuclear condensation without DNA degradation. Mediator of anoikis and a suppressor of beta- catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (By similarity). Regulates granulocytes motility by controlling cell spreading and polarization (PubMed:24163421).|
|Cellular Location||Cytoplasm. Cytoplasmic vesicle, autophagosome lumen|
|Tissue Location||Expressed in peritubular interstitial cells of the renal cortex (PubMed:24906443). Isoform 1 is found in the adult brain while isoform 2 is expressed in brains of embryos and young mice (at protein level) (PubMed:21408167)|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Calcium/calmodulin-dependent serine/threonine kinase which acts as a positive regulator of apoptosis (By similarity).
Liljander, M., et al. Genet. Res. 91(4):259-265(2009)
Fang, J., et al. Blood 112(3):886-890(2008)
Zambrowicz, B.P., et al. Proc. Natl. Acad. Sci. U.S.A. 100(24):14109-14114(2003)
Shimoda, M., et al. J. Exp. Med. 194(11):1597-1607(2001)
Inbal, B., et al. Mol. Cell. Biol. 20(3):1044-1054(2000)
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