|Application ||WB, E|
|Other Accession||Q9UIK4, NP_034149.2|
|Calculated MW||42778 Da|
|Antigen Region||38-65 aa|
|Other Names||Death-associated protein kinase 2, DAP kinase 2, DAP-kinase-related protein 1, DRP-1, Dapk2|
|Target/Specificity||This Mouse Dapk2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-65 amino acids from the N-terminal region of mouse Dapk2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Dapk2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Capable of regulating both type I apoptotic and type II autophagic cell death signals. The former involves caspase activation, chromatin and mitochondrial condensation while the latter involves caspase-independent cell death in conjunction with accumulation of mature autophagic vesicles, plasma membrane blebs, and nuclear condensation without DNA degradation. Mediator of anoikis and a suppressor of beta- catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (By similarity). Regulates granulocytes motility by controlling cell spreading and polarization (PubMed:24163421).|
|Cellular Location||Cytoplasm. Cytoplasmic vesicle, autophagosome lumen|
|Tissue Location||Expressed in peritubular interstitial cells of the renal cortex (PubMed:24906443). Isoform 1 is found in the adult brain while isoform 2 is expressed in brains of embryos and young mice (at protein level) (PubMed:21408167)|
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Provided below are standard protocols that you may find useful for product applications.
Calcium/calmodulin-dependent serine/threonine kinase which acts as a positive regulator of apoptosis (By similarity).
Liljander, M., et al. Genet. Res. 91(4):259-265(2009)
Fang, J., et al. Blood 112(3):886-890(2008)
Zambrowicz, B.P., et al. Proc. Natl. Acad. Sci. U.S.A. 100(24):14109-14114(2003)
Shimoda, M., et al. J. Exp. Med. 194(11):1597-1607(2001)
Inbal, B., et al. Mol. Cell. Biol. 20(3):1044-1054(2000)
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