|Application ||WB, IHC-P, FC, E|
|Other Accession||Q8BM92, Q90763|
|Calculated MW||87086 Da|
|Antigen Region||56-84 aa|
|Other Names||Cadherin-7, CDH7, CDH7L1|
|Target/Specificity||This CDH7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-84 amino acids from the N-terminal region of human CDH7.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CDH7 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
CDH7 is a type II classical cadherin from the cadherin superfamily. This protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Cadherins mediate cell-cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types and the maintenance of orderly structures.
Moore,R., Oncogene 23 (40), 6726-6735 (2004)
Kools,P., Genomics 68 (3), 283-295 (2000)
Shimoyama,Y., Biochem. J. 349 (PT 1), 159-167 (2000)
Kremmidiotis,G., Genomics 49 (3), 467-471 (1998)
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