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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   MINPP1 Antibody (C-term)   

MINPP1 Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - MINPP1 Antibody (C-term) AP14723b
    MINPP1 Antibody (C-term) (Cat. #AP14723b) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the MINPP1 antibody detected the MINPP1 protein (arrow).
    detail
  • FC - MINPP1 Antibody (C-term) AP14723b
    MINPP1 Antibody (C-term) (Cat. #AP14723b) flow cytometric analysis of NCI-H460 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
FC, WB, E
Primary Accession Q9UNW1
Other Accession NP_004888.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 55051 Da
Antigen Region 370-398 aa
Additional Information
Gene ID 9562
Other Names Multiple inositol polyphosphate phosphatase 1, 3-bisphosphoglycerate 3-phosphatase, 3-BPG phosphatase, Inositol (1, 5)-tetrakisphosphate 3-phosphatase, Ins(1, 5)P(4) 3-phosphatase, MINPP1, MIPP
Target/Specificity This MINPP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 370-398 amino acids from the C-terminal region of human MINPP1.
Dilution WB~~1:1000
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMINPP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MINPP1 (HGNC:7102)
Function Multiple inositol polyphosphate phosphatase that hydrolyzes 1D-myo-inositol 1,3,4,5,6-pentakisphosphate (InsP5[2OH]) and 1D-myo- inositol hexakisphosphate (InsP6) to a range of less phosphorylated inositol phosphates. This regulates the availability of these various small molecule second messengers and metal chelators which control many aspects of cell physiology (PubMed:36589890, PubMed:33257696). Has a weak in vitro activity towards 1D-myo-inositol 1,4,5-trisphosphate which is unlikely to be physiologically relevant (PubMed:36589890). By regulating intracellular inositol polyphosphates pools, which act as metal chelators, it may control the availability of intracellular calcium and iron, which are important for proper neuronal development and homeostasis (PubMed:33257696). May have a dual substrate specificity, and function as a 2,3-bisphosphoglycerate 3-phosphatase hydrolyzing 2,3-bisphosphoglycerate to 2-phosphoglycerate. 2,3- bisphosphoglycerate (BPG) is formed as part of the Rapoport-Luebering glycolytic bypass and is a regulator of systemic oxygen homeostasis as the major allosteric effector of hemoglobin (PubMed:18413611).
Cellular Location Endoplasmic reticulum lumen {ECO:0000250|UniProtKB:O35217}. Secreted Cell membrane {ECO:0000250|UniProtKB:Q9Z2L6}. Note=Also associated with the plasma membrane in erythrocytes. {ECO:0000250|UniProtKB:Q9Z2L6}
Tissue Location Widely expressed with highest levels in kidney, liver, cerebellum and placenta.
Research Areas
Citations (0)
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Background

This gene encodes multiple inositol polyphosphate phosphatase; an enzyme that removes 3-phosphate from inositol phosphate substrates. It is the only enzyme known to hydrolzye inositol pentakisphosphate and inositol hexakisphosphate. This enzyme also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate; an activity formerly thought to be exclusive to 2,3-BPG synthase/2-phosphatase (BPGM) in the Rapoport-Luebering shunt of the glycolytic pathway.

References

Newman, A.B., et al. J. Gerontol. A Biol. Sci. Med. Sci. 65(5):478-487(2010)
Cho, J., et al. Proc. Natl. Acad. Sci. U.S.A. 105(16):5998-6003(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)
Liu, T., et al. J. Proteome Res. 4(6):2070-2080(2005)

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$ 182.50
$ 70.00
Cat# AP14723b
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