|Application ||WB, IHC-P, E|
|Other Accession||Q5U305, Q9CQM2, Q2KJ37, Q569A6, Q99JH8, P24390, P33946, Q68ES4, NP_006845.1, NP_001094073.1|
|Predicted||Xenopus, Bovine, Mouse, Rat|
|Calculated MW||24422 Da|
|Antigen Region||183-211 aa|
|Other Names||ER lumen protein-retaining receptor 2, ERD2-like protein 1, ELP-1, KDEL endoplasmic reticulum protein retention receptor 2, KDEL receptor 2, KDELR2, ERD22|
|Target/Specificity||This KDELR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 183-211 amino acids from the C-terminal region of human KDELR2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KDELR2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq].
van der Vlies, D., et al. Biochem. J. 366 (PT 3), 825-830 (2002) :
Pelham, H.R. Cell Struct. Funct. 21(5):413-419(1996)
Lewis, M.J., et al. J. Mol. Biol. 226(4):913-916(1992)
Hsu, V.W., et al. Cell 69(4):625-635(1992)
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