|Application ||WB, IHC-P, E|
|Calculated MW||25390 Da|
|Antigen Region||176-204 aa|
|Other Names||Protein MGARP, Corneal endothelium-specific protein 1, CESP-1, Hypoxia up-regulated mitochondrial movement regulator protein, Mitochondria-localized glutamic acid-rich protein, Ovary-specific acidic protein, MGARP, C4orf49, CESP1, HUMMR, OSAP|
|Target/Specificity||This C4orf49 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 176-204 amino acids from the C-terminal region of human C4orf49.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||C4orf49 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||C4orf49, CESP1, HUMMR, OSAP|
|Function||Plays a role in the trafficking of mitochondria along microtubules. Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia. Participates in the translocation of TRAK2/GRIF1 from the cytoplasm to the mitochondrion. Also plays a role in steroidogenesis through maintenance of mitochondrial abundance and morphology (By similarity).|
|Cellular Location||Membrane; Single-pass membrane protein. Mitochondrion. Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side. Note=Colocalizes with RHOT1, RHOT2, TRAK1 and TRAK2 at the mitochondrion.|
|Tissue Location||Expressed in the brain, adrenal gland and corneal endothelium (CE). Expressed in steroid-producing cells of the ovary and testis (at protein level). Expressed in steroid- producing cells of the ovary and testis. Weakly expressed in placenta. Expressed in corneal endothelial cells|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
The function of this protein remains unknown.
Matsumoto, T., et al. Endocrinology 150(7):3353-3359(2009)
Li, Y., et al. J. Cell Biol. 185(6):1065-1081(2009)
Kinouchi, R., et al. Invest. Ophthalmol. Vis. Sci. 47(4):1397-1403(2006)
Sakai, R., et al. Invest. Ophthalmol. Vis. Sci. 43(6):1749-1756(2002)
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