Register or Login
  • All
  • Uniprot Id
  • Catalog #
  • Peptide Sequence
>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   C4orf49 Antibody (C-term)   

C4orf49 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - C4orf49 Antibody (C-term) AP14729b
    C4orf49 Antibody (C-term) (Cat. #AP14729b) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the C4orf49 antibody detected the C4orf49 protein (arrow).
  • IHC-P - C4orf49 Antibody (C-term) AP14729b
    C4orf49 Antibody (C-term) (AP14729b)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of C4orf49 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8TDB4
Other Accession NP_116012.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 176-204 aa
Additional Information
Other Names Protein MGARP, Corneal endothelium-specific protein 1, CESP-1, Hypoxia up-regulated mitochondrial movement regulator protein, Mitochondria-localized glutamic acid-rich protein, Ovary-specific acidic protein, MGARP, C4orf49, CESP1, HUMMR, OSAP
Target/Specificity This C4orf49 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 176-204 amino acids from the C-terminal region of human C4orf49.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsC4orf49 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms C4orf49, CESP1, HUMMR, OSAP
Function Plays a role in the trafficking of mitochondria along microtubules. Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia. Participates in the translocation of TRAK2/GRIF1 from the cytoplasm to the mitochondrion. Also plays a role in steroidogenesis through maintenance of mitochondrial abundance and morphology (By similarity).
Cellular Location Mitochondrion. Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q8VI64}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q8VI64}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8VI64}. Note=Colocalizes with RHOT1, RHOT2, TRAK1 and TRAK2 at the mitochondrion {ECO:0000250|UniProtKB:Q8VI64}
Tissue Location Expressed in the brain, adrenal gland and corneal endothelium (CE). Expressed in steroid-producing cells of the ovary and testis (at protein level). Expressed in steroid- producing cells of the ovary and testis. Weakly expressed in placenta. Expressed in corneal endothelial cells EMBL; AF484960; AAM09685.1; -; mRNA EMBL; AF329088; AAG59896.1; -; mRNA EMBL; CH471056; EAX05122.1; -; Genomic_DNA EMBL; BC104173; AAI04174.1; -; mRNA EMBL; BC104174; AAI04175.1; -; mRNA CCDS; CCDS43269.1; - RefSeq; NP_116012.2; NM_032623.3 UniGene; Hs.710036; - ProteinModelPortal; Q8TDB4; - SMR; Q8TDB4; - BioGrid; 124220; 2 IntAct; Q8TDB4; 3 STRING; 9606.ENSP00000381928; - iPTMnet; Q8TDB4; - PhosphoSitePlus; Q8TDB4; - BioMuta; MGARP; - DMDM; 74715889; - EPD; Q8TDB4; - PaxDb; Q8TDB4; - PeptideAtlas; Q8TDB4; - PRIDE; Q8TDB4; - Ensembl; ENST00000398955; ENSP00000381928; ENSG00000137463 GeneID; 84709; - KEGG; hsa:84709; - UCSC; uc003ihr.1; human CTD; 84709; - DisGeNET; 84709; - GeneCards; MGARP; - H-InvDB; HIX0200666; - HGNC; HGNC:29969; MGARP HPA; HPA015994; - neXtProt; NX_Q8TDB4; - OpenTargets; ENSG00000137463; - PharmGKB; PA164717327; - eggNOG; ENOG410IWK1; Eukaryota eggNOG; ENOG410Y7BU; LUCA GeneTree; ENSGT00440000037338; - HOGENOM; HOG000111473; - InParanoid; Q8TDB4; - OMA; HTEHITN; - OrthoDB; EOG091G0YRU; - PhylomeDB; Q8TDB4; - TreeFam; TF336324; - GenomeRNAi; 84709; - PRO; PR:Q8TDB4; - Proteomes; UP000005640; Chromosome 4 Bgee; ENSG00000137463; - Genevisible; Q8TDB4; HS GO; GO:1904115; C:axon cytoplasm; IEA:GOC GO; GO:0031307; C:integral component of mitochondrial outer membrane; ISS:UniProtKB GO; GO:0005739; C:mitochondrion; IDA:UniProtKB GO; GO:0008089; P:anterograde axonal transport; ISS:UniProtKB GO; GO:0019896; P:axonal transport of mitochondrion; ISS:UniProtKB GO; GO:0097211; P:cellular response to gonadotropin-releasing hormone; ISS:UniProtKB GO; GO:0071456; P:cellular response to hypoxia; ISS:UniProtKB GO; GO:0071383; P:cellular response to steroid hormone stimulus; ISS:UniProtKB GO; GO:0010822; P:positive regulation of mitochondrion organization; ISS:UniProtKB GO; GO:0006626; P:protein targeting to mitochondrion; ISS:UniProtKB GO; GO:0010821; P:regulation of mitochondrion organization; IBA:GO_Central GO; GO:0008090; P:retrograde axonal transport; ISS:UniProtKB InterPro; IPR026093; MGARP InterPro; IPR032773; MGARP_N PANTHER; PTHR22910; PTHR22910; 1 Pfam; PF14962; AIF-MLS; 1 1: Evidence at protein level; Complete proteome; Membrane; Mitochondrion; Mitochondrion outer membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix CHAIN 1 240 Protein MGARP /FTId=PRO_0000318764 TOPO_DOM 1 40 Cytoplasmic. TRANSMEM 41 63 Helical; Anchor for type IV membrane protein. TOPO_DOM 64 240 Mitochondrial intermembrane VARIANT 128 128 A -> T (in dbSNP:rs3208941) /FTId=VAR_051256 CONFLICT 240 240 G -> RANLQPVDISATNAIGCLISAFVFLVHLV (in Ref. 2; AAG59896). SEQUENCE 240 AA; 25390 MW; 6E210FA627635CEC CRC64; MYLRRAVSKT LALPLRAPPN PAPLGKDASL RRMSSNRFPG SSGSNMIYYL VVGVTVSAGG YYAYKTVTSD QAKHTEHKTN LKEKTKAEIH PFQGEKENVA ETEKASSEAP EELIVEAEVV DAEESPSATV VVIKEASACP GHVEAAPETT AVSAETGPEV TDAAARETTE VNPETTPEVT NAALDEAVTI DNDKDTTKNE TSDEYAELEE ENSPAESESS AGDDLQEEAS VGSEAASAQG
Research Areas
Citations (0)

Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.

Submit your citation using an Abgent antibody to, and receive a free "I Love Antibodies" mug.


The function of this protein remains unknown.


Matsumoto, T., et al. Endocrinology 150(7):3353-3359(2009)
Li, Y., et al. J. Cell Biol. 185(6):1065-1081(2009)
Kinouchi, R., et al. Invest. Ophthalmol. Vis. Sci. 47(4):1397-1403(2006)
Sakai, R., et al. Invest. Ophthalmol. Vis. Sci. 43(6):1749-1756(2002)

Abgent welcomes feedback from its customers.

If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.

If you have any additional inquiries please email technical services at

Cat# AP14729b
(40 western blots)
Availability: Inquire
Bulk Size
Seasonal Special on Bulk Order
Request Quote Here

Ordering Information

United States
AlbaniaAustraliaAustriaBelgiumBosnia & HerzegovinaBrazilBulgariaCanadaCentral AmericaChinaCroatiaCyprusCzech RepublicDenmarkEstoniaFinlandFranceGermanyGreeceHong KongHungaryIcelandIndiaIndonesiaIrelandIsraelItalyJapanLatviaLithuaniaLuxembourgMacedoniaMalaysiaMaltaNetherlandsNew ZealandNorwayPakistanPolandPortugalRomaniaSerbiaSingaporeSlovakiaSloveniaSouth AfricaSouth KoreaSpainSwedenSwitzerlandTaiwanTurkeyUnited KingdomUnited StatesVietnamWorldwideOthers
Abgent, Inc.
(888) 735-7227 / (858) 622-0099
(858) 622-0609
USA Headquarters
(888) 735-7227 / (858) 622-0099 or (858) 875-1900

Shipping Information

Domestic orders (in stock items)
Shipped out the same day. Orders placed after 1 PM (PST) will ship out the next business day.
International orders
Contact your local distributors
Crown Flash21-30% Off
Terms & Conditions