|Application ||WB, E|
|Other Accession||NP_116258.2, NP_001121683.1|
|Calculated MW||66756 Da|
|Antigen Region||194-223 aa|
|Other Names||NudC domain-containing protein 1, Chronic myelogenous leukemia tumor antigen 66, Tumor antigen CML66, NUDCD1 (HGNC:24306)|
|Target/Specificity||This NUDCD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 194-223 amino acids from the Central region of human NUDCD1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NUDCD1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Isoform 1: Cytoplasm. Nucleus. Isoform 3: Cytoplasm. Nucleus.|
|Tissue Location||Isoform 1 is specifically expressed in leukemias and a variety of solid tumor cell lines and is also detected in testis and heart. Isoform 2 is predominantly expressed in testis and weakly expressed in tumor cells|
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Provided below are standard protocols that you may find useful for product applications.
NUDCD1 (CML66) contains 1 CS domain. It may play an oncogenic role in ways of favoring tumor cells proliferation, invasion and metastasis-associated with multiple pathways. NUDCD1 is expressed in leukemias and a variety of solid tumor cell lines. Northern blot analysis showed expression in normal tissues restricted to testis and heart, and no expression was found in hematopoietic tissues.
Wang, Q., et al. Cancer Lett. 269(1):127-138(2008)
Jin, S., et al. Cancer Sci. 99(8):1670-1678(2008)
Yan, Y., et al. J. Immunol. 172(1):651-660(2004)
Yang, X.F., et al. Proc. Natl. Acad. Sci. U.S.A. 98(13):7492-7497(2001)
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