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CDH12 Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - CDH12 Antibody (N-term) AP1473a
    Western blot analysis of anti-CDH12 Antibody (N-term) (RB13742) in Jurkat cell line lysates (35ug/lane). CDH12(arrow) was detected using the purified Pab.
    detail
  • IHC-P - CDH12 Antibody (N-term) AP1473a
    Formalin-fixed and paraffin-embedded human brain tissue reacted with CDH12 antibody (N-term) (Cat.#AP1473a), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P55289
Other Accession Q5RJH3
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 88332 Da
Antigen Region 62-90 aa
Additional Information
Gene ID 1010
Other Names Cadherin-12, Brain cadherin, BR-cadherin, Neural type cadherin 2, N-cadherin 2, CDH12
Target/Specificity This CDH12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 62-90 amino acids from the N-terminal region of human CDH12.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCDH12 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CDH12
Function Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Brain.
Research Areas
Citations (0)
citation

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Background

CDH12 is a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.

References

Shimoyama,Y., Biochem. J. 349 (PT 1), 159-167 (2000)
Chalmers,I.J., Genomics 57 (1), 160-163 (1999)
Kremmidiotis,G., Genomics 49 (3), 467-471 (1998)
Selig,S., Proc. Natl. Acad. Sci. U.S.A. 94 (6), 2398-2403 (1997)

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$ 182.50
$ 70.00
Cat# AP1473a
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