|Application ||WB, E|
|Other Accession||Q4R4K0, Q3ZBA8, NP_963833.1, NP_963831.1, NP_963834.1|
|Calculated MW||40798 Da|
|Antigen Region||42-70 aa|
|Other Names||Protein NDRG2, N-myc downstream-regulated gene 2 protein, Protein Syld709613, NDRG2, KIAA1248, SYLD|
|Target/Specificity||This NDRG2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 42-70 amino acids from the N-terminal region of human NDRG2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NDRG2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation.|
|Cellular Location||Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone. Note=In neurons, seems to concentrate at axonal growth cone. Perinuclear in neurons (By similarity).|
|Tissue Location||Highly expressed in brain, heart, skeletal muscle and salivary gland, and moderately in kidney and liver Expressed in dendritic cells, but not in other blood cells Expression levels are low in pancreatic and liver cancer tissues; absent in meningioma. Expressed in low-grade gliomas but present at low levels in glioblastoma. Isoform 1 and isoform 2 are present in brain neurons and up-regulated in Alzheimer disease (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
Liu, J., et al. Exp. Cell Res. 316(12):1985-1993(2010)
Choi, S.C., et al. Biochem. Biophys. Res. Commun. 396(3):684-690(2010)
Shi, H., et al. Cancer Sci. 101(5):1292-1299(2010)
Tschan, M.P., et al. Leuk. Res. 34(3):393-398(2010)
Furuta, H., et al. Biochem. Biophys. Res. Commun. 391(4):1785-1791(2010)
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