|Application ||WB, IHC-P, E|
|Calculated MW||21118 Da|
|Antigen Region||72-101 aa|
|Other Names||CD70 antigen, CD27 ligand, CD27-L, Tumor necrosis factor ligand superfamily member 7, CD70, CD70, CD27L, CD27LG, TNFSF7|
|Target/Specificity||This CD70 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 72-101 amino acids from the Central region of human CD70.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD70 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CD27L, CD27LG, TNFSF7|
|Function||Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.|
|Cellular Location||Membrane; Single-pass type II membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.
Arimoto-Miyamoto, K., et al. Immunology 130(1):137-149(2010)
Shaw, J., et al. Blood 115(15):3051-3057(2010)
Yu, S.E., et al. Mol. Cells 29(2):217-221(2010)
Kozlowska, A., et al. J. Rheumatol. 37(1):53-59(2010)
Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :
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