|Application ||WB, E|
|Calculated MW||62608 Da|
|Antigen Region||157-186 aa|
|Other Names||Coilin, p80-coilin, COIL, CLN80|
|Target/Specificity||This COIL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 157-186 amino acids from the Central region of human COIL.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||COIL Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs.|
|Cellular Location||Nucleus. Nucleus, Cajal body|
|Tissue Location||Found in all the cell types examined.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14.
Shanbhag, R., et al. FEBS Lett. 584(20):4351-4356(2010)
Tapia, O., et al. Chromosoma 119(5):527-540(2010)
Toyota, C.G., et al. Chromosoma 119(2):205-215(2010)
Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :
Hearst, S.M., et al. J. Cell. Sci. 122 (PT 11), 1872-1881 (2009) :
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