|Application ||WB, E|
|Other Accession||Q99M87, NP_001128582.1, NP_005138.3|
|Calculated MW||52489 Da|
|Antigen Region||105-134 aa|
|Other Names||DnaJ homolog subfamily A member 3, mitochondrial, DnaJ protein Tid-1, hTid-1, Hepatocellular carcinoma-associated antigen 57, Tumorous imaginal discs protein Tid56 homolog, DNAJA3, HCA57, TID1|
|Target/Specificity||This DNAJA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 105-134 amino acids from the N-terminal region of human DNAJA3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DNAJA3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma- mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway.|
|Cellular Location||Mitochondrion matrix. Cytoplasm, cytosol. Cell junction, synapse, postsynaptic cell membrane; Peripheral membrane protein Note=Recruited to the postsynaptic cell membrane of the neuromuscular junction through interaction with MUSK|
|Tissue Location||Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also expressed in keratinocytes|
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Provided below are standard protocols that you may find useful for product applications.
DNAJA3 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins. For background information on the DNAJ family, see MIM 608375.
Qian, J., et al. Gastroenterology 138(4):1418-1428(2010)
Kurzik-Dumke, U., et al. J Transl Med 8, 58 (2010) :
Linnoila, J., et al. Neuron 60(4):625-641(2008)
Kurzik-Dumke, U., et al. Int. J. Mol. Med. 21(1):19-31(2008)
Kurzik-Dumke, U., et al. Cell. Signal. 19(9):1973-1985(2007)
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