|Application ||WB, E|
|Other Accession||Q99M87, NP_001128582.1, NP_005138.3|
|Calculated MW||52489 Da|
|Antigen Region||105-134 aa|
|Other Names||DnaJ homolog subfamily A member 3, mitochondrial, DnaJ protein Tid-1, hTid-1, Hepatocellular carcinoma-associated antigen 57, Tumorous imaginal discs protein Tid56 homolog, DNAJA3, HCA57, TID1|
|Target/Specificity||This DNAJA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 105-134 amino acids from the N-terminal region of human DNAJA3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DNAJA3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma- mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway.|
|Cellular Location||Mitochondrion matrix. Cytoplasm, cytosol. Cell junction, synapse, postsynaptic cell membrane; Peripheral membrane protein Note=Recruited to the postsynaptic cell membrane of the neuromuscular junction through interaction with MUSK|
|Tissue Location||Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also expressed in keratinocytes|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
DNAJA3 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins. For background information on the DNAJ family, see MIM 608375.
Qian, J., et al. Gastroenterology 138(4):1418-1428(2010)
Kurzik-Dumke, U., et al. J Transl Med 8, 58 (2010) :
Linnoila, J., et al. Neuron 60(4):625-641(2008)
Kurzik-Dumke, U., et al. Int. J. Mol. Med. 21(1):19-31(2008)
Kurzik-Dumke, U., et al. Cell. Signal. 19(9):1973-1985(2007)
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