|Application ||WB, IHC-P, E|
|Calculated MW||34291 Da|
|Antigen Region||41-70 aa|
|Other Names||Signal-transducing adaptor protein 1, STAP-1, BCR downstream-signaling protein 1, Docking protein BRDG1, Stem cell adaptor protein 1, STAP1, BRDG1|
|Target/Specificity||This BRDG 1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 41-70 amino acids from the N-terminal region of human BRDG 1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BRDG 1 Antibody (N-term F56) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||In BCR signaling, appears to function as a docking protein acting downstream of TEC and participates in a positive feedback loop by increasing the activity of TEC.|
|Cellular Location||Nucleus. Cytoplasm. Mitochondrion|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
STAP1 functions as a docking protein acting downstream of Tec tyrosine kinase in B cell antigen receptor signaling. The protein is directly phosphorylated by Tec in vitro where it participates in a postive feedback loop, increasing Tec activity.
Ma,J., Atherosclerosis 191 (1), 63-72 (2007)
Beausoleil,S.A., Nat. Biotechnol. 24 (10), 1285-1292 (2006)
Gstaiger,M., Science 302 (5648), 1208-1212 (2003)
Minoguchi,M., J. Biol. Chem. 278 (13), 11182-11189 (2003)
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