BRDG 1 Antibody (N-term F56)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
---|---|
Primary Accession | Q9ULZ2 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 34291 Da |
Antigen Region | 41-70 aa |
Gene ID | 26228 |
---|---|
Other Names | Signal-transducing adaptor protein 1, STAP-1, BCR downstream-signaling protein 1, Docking protein BRDG1, Stem cell adaptor protein 1, STAP1, BRDG1 |
Target/Specificity | This BRDG 1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 41-70 amino acids from the N-terminal region of human BRDG 1. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | BRDG 1 Antibody (N-term F56) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | STAP1 |
---|---|
Synonyms | BRDG1 |
Function | In BCR signaling, appears to function as a docking protein acting downstream of TEC and participates in a positive feedback loop by increasing the activity of TEC. |
Cellular Location | Nucleus. Cytoplasm. Mitochondrion |
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Provided below are standard protocols that you may find useful for product applications.
Background
STAP1 functions as a docking protein acting downstream of Tec tyrosine kinase in B cell antigen receptor signaling. The protein is directly phosphorylated by Tec in vitro where it participates in a postive feedback loop, increasing Tec activity.
References
Ma,J., Atherosclerosis 191 (1), 63-72 (2007)
Beausoleil,S.A., Nat. Biotechnol. 24 (10), 1285-1292 (2006)
Gstaiger,M., Science 302 (5648), 1208-1212 (2003)
Minoguchi,M., J. Biol. Chem. 278 (13), 11182-11189 (2003)
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