|Application ||WB, E|
|Other Accession||Q7ZXP1, Q3B8Q0, Q8R001, Q5ZKK1, Q3SZP2, NP_001137299.1, NP_055083.1, NP_001137298.1|
|Predicted||Bovine, Chicken, Mouse, Rat, Xenopus|
|Calculated MW||37031 Da|
|Antigen Region||12-40 aa|
|Other Names||Microtubule-associated protein RP/EB family member 2, APC-binding protein EB2, End-binding protein 2, EB2, MAPRE2, RP1|
|Target/Specificity||This MAPRE2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-40 amino acids from the N-terminal region of human MAPRE2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MAPRE2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity).|
|Cellular Location||Cytoplasm, cytoskeleton. Note=Associated with the microtubule network. Accumulates at the plus end of microtubules|
|Tissue Location||Expressed in different tumor cell lines. Up- regulated in activated B- and T-lymphocytes|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. The function of this protein is unknown; however, its homology suggests involvement in tumorigenesis of colorectal cancers and proliferative control of normal cells. This gene may belong to the intermediate/early gene family, involved in the signal transduction cascade downstream of the TCR. Alternative splicing results in multiple transcript variants. [provided by RefSeq].
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
De Groot, C.O., et al. J. Biol. Chem. 285(8):5802-5814(2010)
Zhu, Z.C., et al. J. Biol. Chem. 284(47):32651-32661(2009)
Abiatari, I., et al. Int. J. Oncol. 35(5):1111-1116(2009)
Manna, T., et al. Biochemistry 47(2):779-786(2008)
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