|Application ||WB, E|
|Other Accession||P11275, Q9UQM7, NP_803126.1, NP_033922.1|
|Calculated MW||54115 Da|
|Antigen Region||322-349 aa|
|Other Names||Calcium/calmodulin-dependent protein kinase type II subunit alpha, CaM kinase II subunit alpha, CaMK-II subunit alpha, Camk2a|
|Target/Specificity||This Mouse Camk2a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 322-349 amino acids from the C-terminal region of mouse Camk2a.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Camk2a Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity. Phosphorylates transcription factor FOXO3 on 'Ser-298' (By similarity). Activates FOXO3 transcriptional activity (PubMed:23805378).|
|Cellular Location||Isoform Alpha KAP: Cytoplasm. Cell junction, synapse, presynaptic cell membrane Cell junction, synapse. Note=Postsynaptic lipid rafts.|
|Tissue Location||Isoform Alpha CaMKII is expressed in brain while isoform Alpha KAP is expressed in skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity).
Hund, T.J., et al. J. Clin. Invest. 120(10):3508-3519(2010)
Xu, L., et al. Circ. Res. 107(3):398-407(2010)
Guetg, N., et al. Proc. Natl. Acad. Sci. U.S.A. 107(31):13924-13929(2010)
Blaich, A., et al. Proc. Natl. Acad. Sci. U.S.A. 107(22):10285-10289(2010)
Jenkins, M.A., et al. J. Neurosci. 30(15):5125-5135(2010)
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