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A2M Antibody (C-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP14790b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP14790b-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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A2M Antibody (C-term) - Product info | |
| Application | WB
|
| Primary Accession | P01023 |
| Other Accession | NP_000005.2 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 163291 Da |
A2M Antibody (C-term) - Additional info | |
| Gene ID 2 | |
| Other Names A2M; CPAMD5; Alpha-2-macroglobulin; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5 | |
| Target/Specificity This A2M antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1161-1192 amino acids from the C-terminal region of human A2M. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions A2M Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
A2M Antibody (C-term) - Protein Information | |
| Name A2M | |
| Synonyms CPAMD5 | |
| Function Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase | |
| Cellular Location Secreted. | |
| Tissue Location Secreted in plasma. | |
A2M Antibody (C-term) - Related products
A2M Antibody (C-term) - Application data
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A2M Antibody (C-term) (Cat. #AP14790b) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the A2M antibody detected the A2M protein (arrow).
A2M Antibody (C-term) - Research Areas
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BACKGROUND
Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq].
REFERENCES
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) Bruno, E., et al. Neurosci. Lett. 482(2):112-116(2010) Nalpas, B., et al. Gut 59(8):1120-1126(2010) Song, H., et al. Neurosci. Lett. 479(2):143-145(2010) Seriramalu, R., et al. Electrophoresis 31(14):2388-2395(2010)
