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WWOX Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - WWOX Antibody (C-term) AP14792B
    WWOX Antibody (C-term) (Cat. #AP14792b) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the WWOX antibody detected the WWOX protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NZC7
Other Accession NP_057457.1, NP_570607.1
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 46677 Da
Antigen Region 369-396 aa
Additional Information
Gene ID 51741
Other Names WW domain-containing oxidoreductase, 111-, Fragile site FRA16D oxidoreductase, WWOX, FOR, WOX1
Target/Specificity This WWOX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 369-396 amino acids from the C-terminal region of human WWOX.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsWWOX Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms FOR, SDR41C1, WOX1
Function Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.
Cellular Location Cytoplasm. Nucleus. Mitochondrion. Golgi apparatus. Note=Partially localizes to the mitochondria Translocates to the nucleus upon genotoxic stress or TNF stimulation (By similarity). Translocates to the nucleus in response to TGFB1. Isoform 5 and isoform 6 may localize in the nucleus.
Tissue Location Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines Isoform 5 and isoform 6 may only be expressed in tumor cell lines
Research Areas
Citations (0)

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WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms.


Maeda, N., et al. Virchows Arch. 457(4):423-432(2010)
Baykara, O., et al. Tumour Biol. 31(4):315-320(2010)
Kurek, K.C., et al. Cancer Res. 70(13):5577-5586(2010)
Lin, J., et al. Zhonghua Gan Zang Bing Za Zhi 18(5):357-360(2010)
Saez, M.E., et al. BMC Med. Genet. 11, 148 (2010) :

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$ 295.00
$ 99.00
Cat# AP14792B
(40 western blots)
Availability: In Stock
Bulk Size
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