|Application ||WB, IF, FC, E|
|Other Accession||NP_001002033.1, NP_057269.1|
|Calculated MW||16015 Da|
|Antigen Region||58-86 aa|
|Other Names||Hematological and neurological expressed 1 protein, Androgen-regulated protein 2, Hematological and neurological expressed 1 protein, N-terminally processed, HN1, ARM2|
|Target/Specificity||This HN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-86 amino acids from the Central region of human HN1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HN1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Modulates negatively AKT-mediated GSK3B signaling (PubMed:21323578, PubMed:22155408). Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions (PubMed:25169422). Plays a role in the regulation of cell cycle and cell adhesion (PubMed:25169422, PubMed:25450365). Has an inhibitory role on AR- signaling pathway through the induction of receptor proteosomal degradation (PubMed:22155408).|
|Cellular Location||Nucleus. Cytoplasm|
|Tissue Location||Expressed in testis, skeletal muscle, thymus, prostate, colon, peripheral blood cells, brain and placenta|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
HN1 belongs to the HN1 family.
Laughlin, K.M., et al. Pathol. Oncol. Res. 15(3):437-444(2009)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Zougman, A., et al. J. Proteome Res. 5(4):925-934(2006)
Zhou, G., et al. Gene 331, 115-123 (2004) :
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