ALDH8A1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9H2A2 |
Reactivity | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 53401 Da |
Antigen Region | 386-416 aa |
Gene ID | 64577 |
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Other Names | Aldehyde dehydrogenase family 8 member A1, 121-, Aldehyde dehydrogenase 12, ALDH8A1, ALDH12 |
Target/Specificity | This ALDH8A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 386-416 amino acids from the C-terminal region of human ALDH8A1. |
Dilution | WB~~1:2000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | ALDH8A1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ALDH8A1 (HGNC:15471) |
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Synonyms | ALDH12 |
Function | Catalyzes the NAD-dependent oxidation of 2-aminomuconic semialdehyde of the kynurenine metabolic pathway in L-tryptophan degradation. |
Cellular Location | Cytoplasm. |
Tissue Location | Highly expressed in adult kidney and liver. Detected at lower levels in fetal liver and kidney |
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Provided below are standard protocols that you may find useful for product applications.
Background
ALDH8A1 belongs to the aldehyde dehydrogenases family of proteins. It plays a role in a pathway of 9-cis-retinoic acid biosynthesis in vivo. This enzyme converts 9-cis-retinal into the retinoid X receptor ligand 9-cis-retinoic acid, and has approximately 40-fold higher activity with 9-cis-retinal than with all-trans-retinal. Therefore, it is the first known aldehyde dehydrogenase to show a preference for 9-cis-retinal relative to all-trans-retinal.
References
Lin,M.,J. Biol. Chem. 275 (51), 40106-40112 (2000)
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