|Application ||WB, IHC-P, E|
|Other Accession||P83941, P83940, Q2KII4, NP_005639.1|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||12473 Da|
|Antigen Region||69-98 aa|
|Other Names||Transcription elongation factor B polypeptide 1, Elongin 15 kDa subunit, Elongin-C, EloC, RNA polymerase II transcription factor SIII subunit C, SIII p15, TCEB1|
|Target/Specificity||This TCEB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 69-98 amino acids from the C-terminal region of human TCEB1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TCEB1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).|
|Tissue Location||Overexpressed in prostate cancer cell line PC- 3 and breast cancer cell line SK-BR-3|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation.
Marcsisin, S.R., et al. J. Mol. Biol. 402(5):892-904(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Lievens, S., et al. J. Proteome Res. 8(2):877-886(2009)
Jalava, S.E., et al. Int. J. Cancer 124(1):95-102(2009)
Piessevaux, J., et al. J. Biol. Chem. 283(31):21334-21346(2008)
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