|Application ||WB, IF, E|
|Calculated MW||25416 Da|
|Antigen Region||115-145 aa|
|Other Names||CD9 antigen, 5H9 antigen, Cell growth-inhibiting gene 2 protein, Leukocyte antigen MIC3, Motility-related protein, MRP-1, Tetraspanin-29, Tspan-29, p24, CD9, CD9, MIC3, TSPAN29|
|Target/Specificity||This CD9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 115-145 amino acids from the Central region of human CD9.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD9 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion.|
|Cellular Location||Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein|
|Tissue Location||Detected in platelets (at protein level). Expressed by a variety of hematopoietic and epithelial cells|
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Provided below are standard protocols that you may find useful for product applications.
CD9 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It can modulate cell adhesion and migration and also trigger platelet activation and aggregation. In addition, the protein appears to promote muscle cell fusion and support myotube maintenance.
Ovalle,S., Int. J. Cancer 121 (10), 2140-2152 (2007)
Kovalenko,O.V., Mol. Cell Proteomics 6 (11), 1855-1867 (2007)
Abache,T., J. Cell. Biochem. 102 (3), 650-664 (2007)
Horejsi,V., FEBS Lett. 288 (1-2), 1-4 (1991)
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