|Application ||WB, IHC-P, E|
|Calculated MW||16225 Da|
|Antigen Region||39-68 aa|
|Other Names||Alpha-lactalbumin, Lactose synthase B protein, Lysozyme-like protein 7, LALBA, LYZL7|
|Target/Specificity||This LALBA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-68 amino acids from the Central region of human LALBA.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LALBA Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.|
|Tissue Location||Mammary gland specific. Secreted in milk.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes alpha-lactalbumin, a principal protein of milk. Alpha-lactalbumin forms the regulatory subunit of the lactose synthase (LS) heterodimer and beta 1,4-galactosyltransferase (beta4Gal-T1) forms the catalytic component. Together, these proteins enable LS to produce lactose by transfering galactose moieties to glucose. As a monomer, alpha-lactalbumin strongly binds calcium and zinc ions and may possess bactericidal or antitumor activity. A folding variant of alpha-lactalbumin, called HAMLET, likely induces apoptosis in tumor and immature cells.
Tolin, S., et al. FEBS J. 277(1):163-173(2010)
Rosner, H.I., et al. J. Mol. Biol. 394(2):351-362(2009)
Wang, J., et al. J. Dairy Sci. 91(12):4466-4476(2008)
Ramboarina, S., et al. J. Am. Chem. Soc. 130(46):15318-15326(2008)
Morozova, O.B., et al. J Phys Chem B 109(12):5912-5918(2005)
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