|Application ||WB, E|
|Other Accession||P51514, Q61286, NP_996923.1, NP_996919.1|
|Calculated MW||72965 Da|
|Antigen Region||55-84 aa|
|Other Names||Transcription factor 12, TCF-12, Class B basic helix-loop-helix protein 20, bHLHb20, DNA-binding protein HTF4, E-box-binding protein, Transcription factor HTF-4, TCF12, BHLHB20, HEB, HTF4|
|Target/Specificity||This TCF12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-84 amino acids from the N-terminal region of human TCF12.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TCF12 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||BHLHB20, HEB, HTF4|
|Function||Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').|
|Tissue Location||Expressed in several tissues and cell types including skeletal muscle, thymus, and a B-cell line|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq].
Schotte, R., et al. J. Immunol. 184(12):6670-6679(2010)
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Landa, I., et al. PLoS Genet. 5 (9), E1000637 (2009) :
Gardini, A., et al. PLoS Genet. 4 (11), E1000275 (2008) :
Kumar, R., et al. J. Biol. Chem. 283(27):19026-19038(2008)
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