|Application ||WB, E|
|Other Accession||NP_002299.2, NP_033665.1|
|Calculated MW||39518 Da|
|Antigen Region||62-90 aa|
|Other Names||Galectin-9, Gal-9, Ecalectin, Tumor antigen HOM-HD-21, LGALS9|
|Target/Specificity||This LGALS9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 62-90 amino acids from the N-terminal region of human LGALS9.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LGALS9 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds galactosides. Has high affinity for the Forssman pentasaccharide. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. Inhibits cell proliferation. It is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death. Isoform Short acts as an eosinophil chemoattractant.|
|Cellular Location||Cytoplasm. Secreted. Note=May also be secreted by a non-classical secretory pathway.|
|Tissue Location||Peripheral blood leukocytes and lymphatic tissues. Overexpressed in Hodgkin disease tissue|
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Provided below are standard protocols that you may find useful for product applications.
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The protein encoded by this gene is an S-type lectin. It is overexpressed in Hodgkin's disease tissue and might participate in the interaction between the H&RS cells with their surrounding cells and might thus play a role in the pathogenesis of this disease and/or its associated immunodeficiency. Multiple alternatively spliced transcript variants have been found for this gene.
Dardalhon, V., et al. J. Immunol. 185(3):1383-1392(2010)
Tanikawa, R., et al. Biochem. Biophys. Res. Commun. 394(2):317-322(2010)
Katoh, S., et al. Int. Arch. Allergy Immunol. 153(3):294-302(2010)
Niki, T., et al. J. Biol. Chem. 284(47):32344-32352(2009)
Zhang, F., et al. Zhonghua Zhong Liu Za Zhi 31(2):95-98(2009)
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