|Application ||WB, E|
|Other Accession||P97574, O55183, NP_003146.1|
|Calculated MW||27621 Da|
|Antigen Region||193-221 aa|
|Other Names||Stanniocalcin-1, STC-1, STC1, STC|
|Target/Specificity||This STC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 193-221 amino acids from the C-terminal region of human STC1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||STC1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia.|
|Tissue Location||Expressed in most tissues, with the highest levels in ovary, prostate, heart, kidney and thyroid. In the kidney, expression is confined to the nephron, specifically in the distal convoluted tubule and in the collecting tubule. Not detected in the brain, liver, spleen, peripheral blood leukocytes and adrenal medulla|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Liu, G., et al. J. Natl. Cancer Inst. 102(11):812-827(2010)
Kottgen, A., et al. Nat. Genet. 42(5):376-384(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Trindade, D.M., et al. BMC Struct. Biol. 9, 57 (2009) :
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