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TK2 Antibody (C-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP14865b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP14865b-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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TK2 Antibody (C-term) - Product info | |
| Application | WB, IHC
|
| Primary Accession | O00142 |
| Other Accession | NP_001166114.1, NP_004605.4 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 31005 Da |
TK2 Antibody (C-term) - Additional info | |
| Gene ID 7084 | |
| Other Names TK2; Thymidine kinase 2, mitochondrial; Mt-TK | |
| Target/Specificity This TK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 233-263 amino acids from the C-terminal region of human TK2. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions TK2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
TK2 Antibody (C-term) - Protein Information | |
| Name TK2 | |
| Function Deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine. Also phosphorylates anti-viral and anti-cancer nucleoside analogs | |
| Cellular Location Mitochondrion. | |
| Tissue Location Predominantly expressed in liver, pancreas, muscle, and brain | |
TK2 Antibody (C-term) - Related products
AP14865b: TK2 Antibody (C-term)
AP7062a: Thymidine Kinase 2 Antibody (N-term)
AP7062b: Thymidine Kinase 2 Antibody (C-term)
TK2 Antibody (C-term) - Application data
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TK2 Antibody (C-term) (Cat. #AP14865b) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the TK2 antibody detected the TK2 protein (arrow).
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TK2 Antibody (C-term) (AP14865b)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TK2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
TK2 Antibody (C-term) - Research Areas
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BACKGROUND
This gene encodes a deoxyribonucleoside kinase that specifically phosphorylates thymidine, deoxycytidine, and deoxyuridine. The encoded enzyme localizes to the mitochondria and is required for mitochondrial DNA synthesis. Mutations in this gene are associated with a myopathic form of mitochondrial DNA depletion syndrome. Alternate splicing results in multiple transcript variants.
REFERENCES
Davila, S., et al. Genes Immun. 11(3):232-238(2010) Sato, N., et al. Am. J. Hum. Genet. 85(5):544-557(2009) Collins, J., et al. Neuromuscul. Disord. 19(11):784-787(2009) Villarroya, J., et al. Exp. Cell Res. 315(8):1429-1438(2009) Frangini, M., et al. FEBS J. 276(4):1104-1113(2009)
